The Centro de Biotecnología y Genómica de Plantas (CBGP) is a joint research centre of the Universidad Politécnica de Madrid (UPM) and the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). The CBGP (UPM-INIA) holds the recognition of centre of Excellence Severo Ochoa. The strategic objectives of CBGP (UPM-INIA) are the generation of fundamental knowledge on the genetic and molecular bases of key biological and physiological processes in plants and plant-interacting organisms, and on genomics of plants and plant-interacting organisms. The Centre also aims to develop new Computational Biology technologies for the functional analysis of plants/microorganisms. CBGP researchers are grouped into four Research Areas/Themes: Plant Development (8 groups); Interactions of Plants with Environment (8 groups), Biotechnology (4 groups) and Computational/systems Biology and Genomics Program (CsBGP, 5 groups). CBGP has attracted talented scientists since its foundation, including 15 Tenure-track positions and 3 ERC Starting Grants. The centre has a remarkable Translational Biology activity within the innovation ecosystem of the International Campus of Excellence of Montegancedo-UPM, that has resulted in the creation of four CBGP based spin-off enterprises and in the development of new products/processes for the bioeconomy sectors.